Key role of piRNAs in telomeric chromatin maintenance and telomere nuclear positioning in Drosophila germline
Abstract Background Telomeric small RNAs related to PIWI-interacting RNAs (piRNAs) have been described in various eukaryotes; however, their role in germline-specific telomere function remains poorly understood.Using a Drosophila model, we performed an in-depth study of the biogenesis of telomeric piRNAs and their function in telomere homeostasis i