KEY ROLE OF PIRNAS IN TELOMERIC CHROMATIN MAINTENANCE AND TELOMERE NUCLEAR POSITIONING IN DROSOPHILA GERMLINE

Key role of piRNAs in telomeric chromatin maintenance and telomere nuclear positioning in Drosophila germline

Abstract Background Telomeric small RNAs related to PIWI-interacting RNAs (piRNAs) have been described in various eukaryotes; however, their role in germline-specific telomere function remains poorly understood.Using a Drosophila model, we performed an in-depth study of the biogenesis of telomeric piRNAs and their function in telomere homeostasis i

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